The Evolving Landscape of Brain Metastasis

Manuel Valiente, Manmeet S Ahluwalia, Adrienne Boire, Priscilla K Brastianos, Sarah B Goldberg, Eudocia Q Lee, Emilie Le Rhun, Matthias Preusser, Frank Winkler, Riccardo Soffietti,

Trends Cancer

https://doi.org/10.1016/j.trecan.2018.01.003

Abstract

Metastasis, involving the spread of systemic cancer to the brain, results in neurologic disability and death. Current treatments are largely palliative in nature; improved therapeutic approaches represent an unmet clinical need. However, recent experimental and clinical advances challenge the bleak long-term outcome of this disease. Encompassing key recent findings in epidemiology, genetics, microenvironment, leptomeningeal disease, neurocognition, targeted therapy, immunotherapy, and prophylaxis, we review preclinical and clinical studies to provide a comprehensive picture of contemporary research and the management of secondary brain tumors.