PRISM Research on Spatial Omics Featured on the Cover of Molecular & Cellular Proteomics

PRISM is proud to announce that the paper “Predicting Protein Pathways Associated with Tumor Heterogeneity by Correlating Spatial Lipidomics and Proteomics: The Dry Proteomic Concept“ has been featured on the cover of Molecular & Cellular Proteomics. This study, authored by Laurine Lagache, Yanis Zirem, Émilie Le Rhun, Isabelle Fournier, andMichel Salzet, highlights a novel approach to spatial omics, enhancing protein identification through lipid profiling.

Bridging Spatial Lipidomics and Proteomics

The Dry Proteome concept, introduced in this research, explores how lipid molecules serve as key indicators for protein pathways in the tumor microenvironment. By correlating spatial lipidomics and proteomics, the study provides new insights into tumor heterogeneity and advances mass spectrometry imaging (MSI)-guided spatial omics. This innovative approach could improve biomarker discovery and therapeutic targeting in cancer research.

A Striking Visual Representation

The cover illustration, created by Tristan Cardon, visually represents the Dry Proteome. The image portrays a heat mirage in a desert, where a lipid molecule transforms into a protein, symbolizing the crucial role of lipids in guiding protein identification and pathway discovery. This artistic interpretation underscores the significance of spatial omics in biomedical research.

A Step Forward in Spatial Omics

This recognition in Molecular & Cellular Proteomics highlights the impact of PRISM’s work in advancing proteomics and lipidomics. By integrating spatial omics approaches, researchers can better understand tumor biology, disease progression, and potential therapeutic targets.