Soulaimane Aboulouard

  • Engineers

Soulaimane Aboulouard is an engineer and the technical manager of the MS4Omics platform at the PRISM laboratory (INSERM U1192), University of Lille. He joined the laboratory in 2016 as a contractual research engineer (CDD). In 2023, after successfully passing a national competitive examination, he became a permanent staff member. Since 2022, he has been responsible for managing the laboratory’s analytical equipment, which includes over 10 mass spectrometers and 5 liquid chromatography systems.
His work focuses on proteomics, lipidomics, metabolomics, and transcriptomics, with a strong emphasis on research and development. He has contributed to the development of innovative analytical methodologies, including protocols for localized multi-omics analyses on biopsy sections.
Soulaimane has co-authored 26 scientific publications, including 3 as the first author, and has actively participated in organizing scientific events, such as the workshop “EURON Neuroproteomics and Systems Biology.” He is committed to training and mentoring, having supervised 8 interns (Master’s level), trained numerous PhD students and researchers in analytical techniques, and delivered practical sessions in the “Omics and Systems Biology” Master’s program.
In addition to his technical and research responsibilities, Soulaimane holds key institutional roles as a member of the Mixed Commission of the Biology Department and an elected member of the PRISM Laboratory Council.
One of his notable contributions includes collaborative research on breast cancer proteomics in partnership with the Centre Oscar Lambret, which led to significant scientific advancements and high-impact publications.
Soulaimane excels in combining technical expertise, methodological innovation, and strategic management, making a substantial contribution to the scientific and technological excellence of the PRISM laboratory.

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1: Ziane-Chaouche L, Raffo-Romero A, Hajjaji N, Kobeissy F, Pinheiro D,
Aboulouard S, Cozzani A, Mitra S, Fournier I, Cizkova D, Salzet M, Duhamel M.
Inhibition of furin in CAR macrophages directs them toward a proinflammatory
phenotype and enhances their antitumor activities. Cell Death Dis. 2024 Dec
4;15(12):879. doi: 10.1038/s41419-024-07267-4. PMID: 39632807; PMCID:
PMC11618602.

2: Couty N, Estienne A, Le Lay S, Rame C, Chevaleyre C, Allard-Vannier E,
Péchoux C, Guerif F, Vasseur C, Aboulouard S, Salzet M, Dupont J, Froment P.
Human ovarian extracellular vesicles proteome from polycystic ovary syndrome
patients associate with follicular development alterations. FASEB J. 2024 Oct
31;38(20):e70113. doi: 10.1096/fj.202400521RR. PMID: 39436214.

3: Gauvrit T, Benderradji H, Pelletier A, Aboulouard S, Faivre E, Carvalho K,
Deleau A, Vallez E, Launay A, Bogdanova A, Besegher M, Le Gras S, Tailleux A,
Salzet M, Buée L, Delahaye F, Blum D, Vieau D. Multi-Omics Data Integration
Reveals Sex-Dependent Hippocampal Programming by Maternal High-Fat Diet during
Lactation in Adult Mouse Offspring. Nutrients. 2023 Nov 5;15(21):4691. doi:
10.3390/nu15214691. PMID: 37960344; PMCID: PMC10649590.

4: Capuz A, Osien S, Cardon T, Karnoub MA, Aboulouard S, Raffo-Romero A, Duhamel
M, Cizkova D, Trerotola M, Devos D, Kobeissy F, F VA, Bonnefond A, Fournier I,
Rodet F, Salzet M. Correction: Heimdall, an alternative protein issued from a
ncRNA related to kappa light chain variable region of immunoglobulins from
astrocytes: a new player in neural proteome. Cell Death Dis. 2023 Oct
13;14(10):677. doi: 10.1038/s41419-023-06143-x. Erratum for: Cell Death Dis.
2023 Aug 16;14(8):526. doi: 10.1038/s41419-023-06037-y. PMID: 37833264; PMCID:
PMC10576076.

5: Wisztorski M#, Aboulouard S#, Roussel L#, Duhamel M#, Saudemont P, Cardon T,
Narducci F, Robin YM, Lemaire AS, Bertin D, Hajjaji N, Kobeissy F, Leblanc E,
Fournier I, Salzet M. Fallopian tube lesions as potential precursors of early
ovarian cancer: a comprehensive proteomic analysis. Cell Death Dis. 2023 Sep
30;14(9):644. doi: 10.1038/s41419-023-06165-5. PMID: 37775701; PMCID:
PMC10541450.

6: Capuz A, Osien S, Cardon T, Karnoub MA, Aboulouard S, Raffo-Romero A, Duhamel
M, Cizkova D, Trerotola M, Devos D, Kobeissy F, Vanden Abeele F, Bonnefond A,
Fournier I, Rodet F, Salzet M. Heimdall, an alternative protein issued from a
ncRNA related to kappa light chain variable region of immunoglobulins from
astrocytes: a new player in neural proteome. Cell Death Dis. 2023 Aug
16;14(8):526. doi: 10.1038/s41419-023-06037-y. Erratum in: Cell Death Dis. 2023
Oct 13;14(10):677. doi: 10.1038/s41419-023-06143-x. PMID: 37587118; PMCID:
PMC10432539.

7: Capuz A, Osien S, Karnoub MA, Aboulouard S, Laurent E, Coyaud E, Raffo-Romero
A, Duhamel M, Bonnefond A, Derhourhi M, Trerotola M, El Yazidi-Belkoura I, Devos
D, Zilkova M, Kobeissy F, Vanden Abeele F, Fournier I, Cizkova D, Rodet F,
Salzet M. Astrocytes express aberrant immunoglobulins as putative gatekeeper of
astrocytes to neuronal progenitor conversion. Cell Death Dis. 2023 Apr
4;14(4):237. doi: 10.1038/s41419-023-05737-9. PMID: 37015912; PMCID:
PMC10073301.

8: Folon L, Baron M, Toussaint B, Vaillant E, Boissel M, Scherrer V, Loiselle H,
Leloire A, Badreddine A, Balkau B, Charpentier G, Franc S, Marre M, Aboulouard
S, Salzet M, Canouil M, Derhourhi M, Froguel P, Bonnefond A. Contribution of
heterozygous PCSK1 variants to obesity and implications for precision medicine:
a case-control study. Lancet Diabetes Endocrinol. 2023 Mar;11(3):182-190. doi:
10.1016/S2213-8587(22)00392-8. PMID: 36822744.

9: Raffo-Romero A, Aboulouard S, Bouchaert E, Rybicka A, Tierny D, Hajjaji N,
Fournier I, Salzet M, Duhamel M. Establishment and characterization of canine
mammary tumoroids for translational research. BMC Biol. 2023 Feb 3;21(1):23.
doi: 10.1186/s12915-023-01516-2. PMID: 36737789; PMCID: PMC9898911.

10: Duhamel M, Drelich L, Wisztorski M, Aboulouard S, Gimeno JP, Ogrinc N, Devos
P, Cardon T, Weller M, Escande F, Zairi F, Maurage CA, Le Rhun É, Fournier I,
Salzet M. Spatial analysis of the glioblastoma proteome reveals specific
molecular signatures and markers of survival. Nat Commun. 2022 Nov 4;13(1):6665.
doi: 10.1038/s41467-022-34208-6. PMID: 36333286; PMCID: PMC9636229.

11: Hajjaji N, Aboulouard S, Cardon T, Bertin D, Robin YM, Fournier I, Salzet M.
Path to Clonal Theranostics in Luminal Breast Cancers. Front Oncol. 2022 Jan
13;11:802177. doi: 10.3389/fonc.2021.802177. PMID: 35096604; PMCID: PMC8793283.

12: Rose M, Cardon T, Aboulouard S, Hajjaji N, Kobeissy F, Duhamel M, Fournier
I, Salzet M. Surfaceome Proteomic of Glioblastoma Revealed Potential Targets for
Immunotherapy. Front Immunol. 2021 Sep 27;12:746168. doi:
10.3389/fimmu.2021.746168. PMID: 34646273; PMCID: PMC8503648.

13: Drelich L, Aboulouard S, Franck J, Salzet M, Fournier I, Wisztorski M.
Toward High Spatially Resolved Proteomics Using Expansion Microscopy. Anal Chem.
2021 Sep 14;93(36):12195-12203. doi: 10.1021/acs.analchem.0c05372. Epub 2021 Aug
27. PMID: 34449217.

14: Aboulouard S, Wisztorski M, Duhamel M, Saudemont P, Cardon T, Narducci F,
Lemaire AS, Kobeissy F, Leblanc E, Fournier I, Salzet M. In-depth proteomics
analysis of sentinel lymph nodes from individuals with endometrial cancer. Cell
Rep Med. 2021 Jun 15;2(6):100318. doi: 10.1016/j.xcrm.2021.100318. PMID:
34195683; PMCID: PMC8233695.

15: Malaker SA, Quanico J, Raffo-Romero A, Kobeissy F, Aboulouard S, Tierny D,
Bertozzi CR, Fournier I, Salzet M. On-tissue spatially resolved glycoproteomics
guided by N-glycan imaging reveal global dysregulation of canine glioma
glycoproteomic landscape. Cell Chem Biol. 2022 Jan 20;29(1):30-42.e4. doi:
10.1016/j.chembiol.2021.05.007. Epub 2021 Jun 7. PMID: 34102146; PMCID:
PMC8617081.

16: Rose M, Duhamel M, Aboulouard S, Kobeissy F, Tierny D, Fournier I, Rodet F,
Salzet M. Therapeutic anti-glioma effect of the combined action of PCSK
inhibitor with the anti-tumoral factors secreted by Poly (I:C)-stimulated
macrophages. Cancer Gene Ther. 2022 Jan;29(1):22-36. doi:
10.1038/s41417-020-00286-1. Epub 2021 Jan 5. PMID: 33402730; PMCID: PMC8761570.

17: Cardon T, Ozcan B, Aboulouard S, Kobeissy F, Duhamel M, Rodet F, Fournier I,
Salzet M. Epigenetic Studies Revealed a Ghost Proteome in PC1/3 KD Macrophages
under Antitumoral Resistance Induced by IL-10. ACS Omega. 2020 Oct
1;5(43):27774-27782. doi: 10.1021/acsomega.0c02530. PMID: 33163760; PMCID:
PMC7643081.

18: Murgoci AN, Cardon T, Aboulouard S, Duhamel M, Fournier I, Cizkova D, Salzet
M. Reference and Ghost Proteins Identification in Rat C6 Glioma Extracellular
Vesicles. iScience. 2020 May 22;23(5):101045. doi: 10.1016/j.isci.2020.101045.
Epub 2020 Apr 10. PMID: 32334413; PMCID: PMC7182720.

19: Rose M, Duhamel M, Aboulouard S, Kobeissy F, Le Rhun E, Desmons A, Tierny D,
Fournier I, Rodet F, Salzet M. The Role of a Proprotein Convertase Inhibitor in
Reactivation of Tumor-Associated Macrophages and Inhibition of Glioma Growth.
Mol Ther Oncolytics. 2020 Mar 31;17:31-46. doi: 10.1016/j.omto.2020.03.005.
PMID: 32300641; PMCID: PMC7152595.

20: Murgoci AN, Duhamel M, Raffo-Romero A, Mallah K, Aboulouard S, Lefebvre C,
Kobeissy F, Fournier I, Zilkova M, Maderova D, Cizek M, Cizkova D, Salzet M.
Location of neonatal microglia drives small extracellular vesicles content and
biological functions in vitro. J Extracell Vesicles. 2020 Feb
18;9(1):1727637. doi: 10.1080/20013078.2020.1727637. PMID: 32158520; PMCID:
PMC7049881.

21: Mallah K, Quanico J, Raffo-Romero A, Cardon T, Aboulouard S, Devos D,
Kobeissy F, Zibara K, Salzet M, Fournier I. Matrix-Assisted Laser
Desorption/Ionization-Mass Spectrometry Imaging of Lipids in Experimental Model
of Traumatic Brain Injury Detecting Acylcarnitines as Injury Related Markers.
Anal Chem. 2019 Sep 17;91(18):11879-11887. doi: 10.1021/acs.analchem.9b02633.
Epub 2019 Aug 28. PMID: 31412203.

22: Humenik F, Cizkova D, Cikos S, Luptakova L, Madari A, Mudronova D, Kuricova
M, Farbakova J, Spirkova A, Petrovova E, Cente M, Mojzisova Z, Aboulouard S,
Murgoci AN, Fournier I, Salzet M. Canine Bone Marrow-derived Mesenchymal Stem
Cells: Genomics, Proteomics and Functional Analyses of Paracrine Factors. Mol
Cell Proteomics. 2019 Sep;18(9):1824-1835. doi: 10.1074/mcp.RA119.001507. Epub
2019 Jul 8. PMID: 31285283; PMCID: PMC6731083.

23: Mallah K, Quanico J, Raffo-Romero A, Cardon T, Aboulouard S, Devos D,
Kobeissy F, Zibara K, Salzet M, Fournier I. Mapping Spatiotemporal
Microproteomics Landscape in Experimental Model of Traumatic Brain Injury
Unveils a link to Parkinson’s Disease. Mol Cell Proteomics. 2019
Aug;18(8):1669-1682. doi: 10.1074/mcp.RA119.001604. Epub 2019 Jun 16. PMID:
31204315; PMCID: PMC6683007.

24: Raffo-Romero A, Arab T, Van Camp C, Lemaire Q, Wisztorski M, Franck J,
Aboulouard S, Le Marrec-Croq F, Sautiere PE, Vizioli J, Salzet M, Lefebvre C.
ALK4/5-dependent TGF-β signaling contributes to the crosstalk between neurons
and microglia following axonal lesion. Sci Rep. 2019 May 3;9(1):6896. doi:
10.1038/s41598-019-43328-x. PMID: 31053759; PMCID: PMC6499822.