
Francesco Vari
I am a PhD student in pharmacology and toxicology at the University Sapienza of Rome, in collaboration with the University of Salento. My research is focused on lipid metabolism, with a particular focus on the liver and intestine—two key organs involved in the regulation of metabolic processes. Throughout my doctoral studies, I have sought to understand how lipid metabolism influences various physiological functions and plays a role in the development of metabolic disorders.
Currently, I am a visiting PhD researcher at the PRISM laboratory at the University of Lille, where my work focuses on characterizing the pharmacokinetics and intestinal effects of N-oleylethanolamide (OEA), an endocannabinoid-like compound. To investigate this, I utilize advanced proteomic, lipidomic and metabolomic profiling techniques, which allow me to explore OEA’s impact on lipid metabolism and its broader biological activities.
Lipotoxicity of palmitic acid is associated with DGAT1 downregulation and abolished by PPARα activation in liver cells C. Moliterni et al., Journal of lipid research, 2024. DOI: 10.1016/j.jlr.2024.100692.
M1-derived extracellular vesicles polarize recipient macrophages into M2 and alter skeletal muscle homeostasis in a hyper-glucose environment S. Tacconi et al., Cell signaling and comunication, 2024. DOI: 10.1186/s12964-024-01560-7.
Wild-Type and SOD1-G93A SH-SY5Y under Oxidative Stress: EVs Characterization and Topographical Distribution of Budding Vesicles. C. Sbarigia et al., Applied Nano, 2024. DOI: 10.3390/applnano4010004.