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Dr. Françoise Le Marrec

Associate Professor at University Lille 1


University Lille 1
Bât SN3, 1er étage, porte 117

Tel : +33 (0)3 20 43 41 27
Fax : +33 (0)3 20 43 40 54

Email : Francoise.Croq@univ-lille1.fr

45 years old.
Associate Professor (Maître de Conférences)
Research member of the « Microglial Activation Axis » in the laboratory.
CNU Section, 68

Education
• Since 2001, Associate Professor (MCF), Lille 1 University.
• 1995-1997, Temporary assistant professor (ATER) position, Brest University, Pr. M.LE Pennec
• July 1995, PhD in Oceanology Biology (grant cofinanced by a company (BIOPREDIC) and regional council), Brest University supervised by Dr. G.Dorange and Pr. M. Le Pennec. Establishment of primary cultures of marine bivalve cells.
Le Marrec-Croq., Dorange G. and Chesné C. Patent Fr. N° 9506921

Research Activity
The aim of our project is based on the study of microglial cells in the leech Hirudo medicinalis. The neuro-inflammatory processes, in the leech, are considered as unusual since the natural repair of the nerve cord has been observed. Four weeks following a CNS section, the animal is able to restore the lost locomotive functions of the region which is innervated by damaged neurons. In this regeneration of the injured nerve cord, the microglial cells are rapidly recruited to the lesion site through an important chemotactic mechanism. Their accumulation is essential to the axon growth leading to the new synaptic connections. In the context of the innate nerve repair in the medicinal leech, the « Microglial Activation » group is studying (i) the different chemotactic factors which contribute to the microglial accumulation and (ii) the crosstalk between activated microglia and damaged neurons which are able to reconnect.

Funding
• Participant (50%) of ANR JC, SVSE4 (Neurosciences) for the MIMIC project (Microglial implication in the modulation of inflammation in the leech CNS) (2012-2015)

Professional Activities
• Team member of the « Microglial Activation » group specialized in cell culture.
• Teacher (lectures and lab. work) in comparative Biology, Zoologie and preparation for future professors (CAPES preparationVocational Certificate in the teaching profession of the secondary education,).
• Teacher referring for students of first year in the University.
• Responsible for the sector cell culture in the lab.
• Member of the selection committee for assistant professor position in the University of Lille 1 (CNU, section 68)
• Co-supervised Master students (Dely Virginie 2007; Bocquet-Garçon Annelise 2008; Virtuose David 2012)

Recent publications
Tasiemski A, Schikorski D, Le Marrec-Croq F, van Camp C, Boisdin-Wichlacz C, Sautière P.E : Hedistin: A novel antimicrobial peptide containing bromotryptophan constitutively expressed in the NK cells-like of the marine annelid, Nereis diversicolor. Dev.Comp.Immunol 2007, 31:749-762.
Tahtouh M, Croq F, Vizioli J, van Camp C, Salzet M, Daha M, Lefebvre C, Pestel J: A C1q domain containing factor evidenced in the leech nerve cord expressed a chemotactic activity on microglial cells. Mol Immunol 2008, 45:4141-4141.
Tahtouh M, Croq F, Lefebvre C, Pestel J: Is complement good, bad, or both? New functions of the complement factors associated with inflammation mechanisms in the central nervous system. Eur Cytokine Netw 2009, 20:95-100.
Tahtouh M, Croq F, Vizioli J, Sautiere PE, Van Camp C, Salzet M, Daha MR, Pestel J, Lefebvre C: Evidence for a novel chemotactic C1q domain-containing factor in the leech nerve cord. Mol Immunol 2009, 46:523-531.
Croq F, Vizioli J, Tuzova M, Tahtouh M, Sautiere PE, Van Camp C, Salzet M, Cruikshank WW, Pestel J, Lefebvre C: A homologous form of human interleukin 16 is implicated in microglia recruitment following nervous system injury in leech Hirudo medicinalis. Glia 2010, 58:1649-1662.
Croq F, Garçon-Bocquet A, Vizioli J, VanCamp C, Sautiere PE, Salzet M, Lefebvre C: Microglia Activation: Studies on Leeches to Dissect out the Basic Mechanisms of Neuroinflammation. Glia 2011, 59:S135-S135.
Garçon A, Tahtouh M, Croq F, Nagnan-Le Meillour P, Cruikshank W, Daha MR, Lefebvre C, Pestel J: Molecular and Functional Characterization of New Invertebrate Factors Involved in the Specific Microglial Cell Recruitment. Inflammation Research 2011, 60:212-213.
Vizioli J, Accorsi A, Croq F, Bocquet-Garçon A, Van Camp C, Ziental N, Salzet M, Lefebvre C, Sautiere PE: Neuroinflammation and Microglia Activation Studies: a Novel Strategy Using an Invertebrate Model, the Medicinal Leech. Glia 2011, 59:S153-S153.
Tahtouh M, Garçon-Bocquet A, Croq F, Vizioli J, Sautiere PE, Van Camp C, Salzet M, Nagnan-Le Meillour P, Pestel J, Lefebvre C: Interaction of HmC1q with leech microglial cells: involvement of C1qBP-related molecule in the induction of cell chemotaxis. J Neuroinflammation 2012, 9:37.